Willem van Otterlo - Collaborations (www.willemvanotterlo.co.za) - Printer-Friendly Page

 
 


INDUSTRIAL COLLABORATIONS

* 2000 (January - April), Hanessian Laboratories, University of Montreal, Canada - AstraZeneca, Gothenburg, Sweden Research Project. 2-Piperidone Library (Series 4): Synthesis of 80 compound library for biological screening by W.A.L. van Otterlo and M. Seid.

* 2001 (January - May), Hanessian Laboratories, University of Montreal, Canada - AstraZeneca, Gothenburg, Sweden Research Project. Synthesis of Aromatic P2 Scaffolds as Potential Thrombin Inhibitors for biological screening by W.A.L. van Otterlo and M. Bayrakdarian.

* 2003-2004, SASOL, Research & Development. Initiation of projects involving aromatic organic chemistry, C.B. de Koning, W.A.L. van Otterlo, M. Greene, D. Young, B. Bezuidenhout and C. Dwyer.

* 2007 (until present), CSIR, Modderfontein. Medicinal Chemistry Projects): Variety of collaborations with the CSIR involving anti-malarial projects, C.B. de Koning, W.A.L. van Otterlo, A. Rousseau, S. Pelly and E. M. Mmutlane.

* 2010 (until present), NECSA, Broederstroom, Pretoria. Medicinal Chemistry and Fluorine Beneficiation Projects): Variety of collaborations with the NECSA involving the incorporation of 18F into bioactive compounds and the incorporation of fluorine into aromatic compounds, D. van der Westhuizen, C. Wagener, J.-R. Zeevaart, W.A.L. van Otterlo, T.S. Sello and E.L. Ngidi.

COLLABORATIONS WIT OTHER SOUTH AFRICAN UNIVERSITIES:

* 2006 (until present), Research Niche Area (RNA). Synthesis and in vitro screening of potentially bioactive compounds: Main areas of collaboration: Anti-cancer testing with Dr H. Davids (School of Pharmacy and Pharmacology), anti-microbial testing with Mrs S van Vuuren (School of Pharmacy and Pharmacology), anti-malarial testing with Drs RL van Zyl and L Harmse (School of Pharmacy and Pharmacology).

* 2007 (until present), Non-viral gene transfer agents: Main areas of collaboration: Design, synthesis and testing of cholesterol-based compounds as transfection agents with Prof P Arbuthnot of the Antiviral Gene Therapy Research Unit at the Department of Molecular Medicine and Haematology, University of the Witwatersrand.


COLLABORATIONS WITH OTHER UNIVERSITIES:

* 2004 (until present) A. Kornienko, New Mexico Institute of Mining and Technology, Soccorro, USA. Synthesis of anti-cancer pancratistatin analogues: Project aims to synthesize a number of analogues based on the anti-leukemia natural product, pancratistatin.

* 2006 (until present) Dr F. Gagosz, Ecole Polytechnique-CNRS, Paliseau, Paris, France. Utilization of gold catalyst to novel bioactive molecules: Project aims to synthesis a number of nitrogen-containing alkaloid analogues using gold-mediated catalysis.






   


Telephone (Work): + 27 21 808 3344 Fax: + 27 21 808 3360   

 
E-mail: wvo@sun.ac.za
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