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Organic Chemistry at Wits University, Johannesburg, South Africa.
Current research and areas of interest. See past and present students OR join the team! Published papers. Collaboratotions. Latest news Contact Willem. Curriculum Vitae of Willem van Otterlo.
 
 

INDUSTRIAL COLLABORATIONS

* 2000 (January - April), Hanessian Laboratories, University of Montreal, Canada - AstraZeneca, Gothenburg, Sweden Research Project. 2-Piperidone Library (Series 4): Synthesis of 80 compound library for biological screening by W.A.L. van Otterlo and M. Seid.

* 2001 (January - May), Hanessian Laboratories, University of Montreal, Canada - AstraZeneca, Gothenburg, Sweden Research Project. Synthesis of Aromatic P2 Scaffolds as Potential Thrombin Inhibitors for biological screening by W.A.L. van Otterlo and M. Bayrakdarian.

* 2007 (until present), CSIR, Modderfontein. Medicinal Chemistry Projects): Variety of collaborations with the CSIR involving anti-malarial projects, C.B. de Koning, W.A.L. van Otterlo, A. Rousseau, S. Pelly and E. M. Mmutlane.

* 2010 (until present), NECSA, Broederstroom, Pretoria. Medicinal Chemistry and Fluorine Beneficiation Projects): Variety of collaborations with the NECSA involving the incorporation of 18F into bioactive compounds and the incorporation of fluorine into aromatic compounds, D. van der Westhuizen, C. Wagener, J.-R. Zeevaart, W.A.L. van Otterlo, T.S. Sello and E.L. Ngidi.

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COLLABORATIONS WITH OTHER SOUTH AFRICAN UNIVERSITIES:

* 2006 (until present), Research Niche Area (RNA). Synthesis and in vitro screening of potentially bioactive compounds: Main areas of collaboration: Anti-cancer testing with Dr H. Davids (School of Pharmacy and Pharmacology), anti-microbial testing with Mrs S van Vuuren (School of Pharmacy and Pharmacology), anti-malarial testing with Drs RL van Zyl and L Harmse (School of Pharmacy and Pharmacology).

* 2007 (until present), Non-viral gene transfer agents: Main areas of collaboration: Design, synthesis and testing of cholesterol-based compounds as transfection agents with Prof P Arbuthnot of the Antiviral Gene Therapy Research Unit at the Department of Molecular Medicine and Haematology, University of the Witwatersrand.

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COLLABORATIONS WITH OTHER UNIVERSITIES:

* 2004 (until present) A. Kornienko, New Mexico Institute of Mining and Technology, Soccorro, USA. Synthesis of anti-cancer pancratistatin analogues: Project aims to synthesize a number of analogues based on the anti-leukemia natural product, pancratistatin.

* 2006 (until present) Dr F. Gagosz, Ecole Polytechnique-CNRS, Paliseau, Paris, France. Utilization of gold catalyst to novel bioactive molecules: Project aims to synthesis a number of nitrogen-containing alkaloid analogues using gold-mediated catalysis.



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