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 < PUBLICATIONS

(1) The Neutral Oxygen Donor in Complexes of Lead and Cadmium: A Differential Pulse Polarographic, Potentiometric and Calorimetric Study, Polyhedron, 14, 1995, 1661-1674, I. Cukrowski,* F. Marsicano, R.D. Hancock, P.T. Tshetlho and W.A.L. van Otterlo.

(2) The Synthesis of Novel Oxygen-Containing Ligands Derived from Amine Precursors, Tetrahedron Letters, 38, 1997, 1261-1264, C.B. de Koning,* R.D. Hancock and W.A.L. van Otterlo.

(3) Synthesis of an Isochroman Analogue of the Michellamines, Tetrahedron Letters, 40, 1999, 3037-3040, C.B. de Koning,* J.P. Michael and W.A.L. van Otterlo.

(4) Syntheses of Isochroman Analogues of the Michellamines and Korupensamines, Journal of the Royal Chemistry Society, Perkin Transactions 1, 2000, 799-811, C.B. de Koning,* J.P. Michael and W.A.L. van Otterlo.

(5) From Serine to Funtionalized Enantiopure Tetrahydroisoquinolines, Tetrahedron Letters, 41, 2000, 4999-5003; S. Hanessian,* E. Dumont and W.A.L. van Otterlo.

(6) Stereocontrolled Synthesis of a Prototype Library of Enantiopure 2,4-Disubstituted 4-Aryl 6-piperidones and Piperidines, Tetrahedron Letters, 43, 2002, 1995-1998, S. Hanessian,* W.A.L. van Otterlo, I. Nilsson and U. Bauer.

(7) Synthesis of N-Acetyl-1,3-dimethyltetrahydroisoquinolines by Intramolecular Amidomercuration: Stereochemical Consequences, Synlett, 2002, 2065-2067, C.B. de Koning,* J.P. Michael and W.A.L. van Otterlo.

(8) Ring-closing Metathesis for the Synthesis of Benzo-fused Bicyclic Compounds, Tetrahedron Letters, 44, 2003, 311-313; W.A.L. van Otterlo,* E.L. Ngidi, E.M. Coyanis and C.B. de Koning.

(9) Recent Methods for the synthesis of Substituted Naphthalenes, Tetrahedron, 59, 2003, 7-36, C.B. de Koning,* A.L. Rousseau and W.A.L. van Otterlo.*

(10) The Synthesis of Naphtho[a]carbazoles and Benzo[c]carbazoles, Synlett, 2003, 705-707, C.B. de Koning,* J.P. Michael, J.M. Nhlapo, R. Pathak and W.A.L. van Otterlo.

(11) Sequential Isomerization and Ring-closing Metathesis: Masked Styryl and Vinyloxyaryl Groups for the Synthesis of Benzo-fused Heterocycles, Tetrahedron Letters, 44, 2003, 6483-6486; W.A.L. van Otterlo,* E.L. Ngidi and C.B. de Koning.

(12) Ruthenium-mediated Isomerization and Ring-closing Metathesis: Versatile Syntheses of 6-, 7- and 8-Membered Benzo-fused Heterocycles, Synlett, 2003, 1859-1861, W.A.L. van Otterlo,* R. Pathak and C.B. de Koning.*

(13) Amide Rotamers of N-Acetyl-1,3-dimethyltetrahydroisoquinolines: Synthesis, Variable Temperature NMR Spectroscopy and Molecular Modelling, Tetrahedron, 59, 2003, 8337-8345, C.B. de Koning,* W.A.L. van Otterlo* and J.P. Michael.

(14) Synthesis of dienynes from alkenes and diynes using ruthenium-mediated ring-closing metathesis, Tetrahedron Letters, 45, 2004, 659-662, W.A.L. van Otterlo,* E.L. Ngidi, C.B. de Koning and M.A. Fernandes.

(15) The synthesis of indolo- and pyrrolo[2,1-a]isoquinolines, Tetrahedron Letters, 45, 2004, 1117-1119, C.B. de Koning,* J.P. Michael, R. Pathak and W.A.L. van Otterlo.

(16) Unforeseen Formation of 2-Bromo-3-hydroxybenzaldehyde by Bromination of 3-Hydroxybenzaldehyde, Tetrahedron Letters, 45, 2004, 5091-5094, W.A.L. van Otterlo, J.P. Michael, M.A. Fernandes and C.B. de Koning.*

(17) The synthesis of angular polyaromatic compounds by using a light assisted potassium t-butoxide cyclisation reaction, Organic and Biomolecular Chemistry, 2, 2004, 3504-3509, R. Pathak, K. Vandayar, W.A.L. van Otterlo, J.P. Michael, M.A. Fernandes and C.B. de Koning.*

(18) Isomerization and ring-closing metathesis for the synthesis of 6-, 7- and 8-membered benzo- and pyrido-fused N,N-, N,O- and N,S-heterocycles, Tetrahedron Letters, 45, 2004, 9171-9175, W.A.L. van Otterlo,* G.L. Morgans, S.D. Khanye, B.A.A. Aderibigbe, J.P. Michael and D.G. Billing.

(19) The synthesis of 3-methyl- and 3,4-dimethyltetrahydroisoquinolines by Intramolecular hydroamination with n-butyllithium, Tetrahedron Letters, 45, 2004, 9561-9563, W.A.L. van Otterlo,* R. Pathak, M.A. Fernandes and C.B. de Koning.

(20) Base- and Light-assisted Synthesis of Anthracenes from 3- Allylnapththalene-2-carbaldehydes, Tetrahedron, 61, 2005, 555-564, C.B. de Koning,* S.S. Manzini, J.P. Michael, E.M. Mmutlane, T.R. Tshabidi and W.A.L. van Otterlo.

(21) Tandem catalysis: A ring-closing metathesis followed by dehydrogenative oxidation to afford substituted indenones, Synlett, 2005, 501-505, W.A.L. van Otterlo,* E.M. Coyanis, J.-L. Panayides, C.B. de Koning and M.A. Fernandes.

(22) An isomerization-ring-closing metathesis strategy for the synthesis of substituted benzo[b]furans, Tetrahedron, 61, 2005, 7746-7755, W.A.L. van Otterlo,* G.L. Morgans, L.G. Madeley, S. Kuzvidza, S.S. Moleele, N. Thornton and C.B. de Koning.

(23) Ring-closing metathesis for the synthesis of 2H- and 4H-chromenes, Tetrahedron, 61, 2005, 9996-10006, W.A.L. van Otterlo,* E.L. Ngidi, S. Kuzvidza, G.L. Morgans, S.S. Moleele and C.B. de Koning.

(24) Metathesis Reactions for the Synthesis of Ring Fused Carbazoles, Journal of Organic Chemistry, 70, 2005, 10474-10481, S.C. Pelly, C.J. Parkinson, W.A.L. van Otterlo, C.B. de Koning.*

(25) Phenolic P2/P3 core motif as thrombin inhibitors-Design, synthesis, and X-ray co-crystal structure, Bioorganic and Medicinal Letters, 16, 2006, 1032-1036, S. Hanessian,* E. Therrien, W.A.L. van Otterlo, M. Bayrakdarian, O. Fjellström, I. Nilsson and Y. Xue.

(26) A Concise Synthesis of Novel Naphtho[a]carbazoles and Benzo[c]carbazoles, Tetrahedron, 62 2006, 2820-2830, R. Pathak, J.M. Nhlapo, S. Govender, J.P. Michael, W.A.L. van Otterlo and C.B. de Koning.*

(27) Ring-closing metathesis for the synthesis of substituted indenols, indenones, indanones and indenes: tandem RCM-dehydrogenative oxidation and RCM-redox isomerization, Journal of Organometallic Chemistry, 691, 2006, 5222-5239, E.M. Coyanis, J.-L. Panayides, M.A. Fernandes, C.B. de Koning and W.A.L. van Otterlo.*

(28) The synthesis of 5-, 6-, 7- and 8-membered oxygen-containing benzo-fused rings using alkene isomerisation and ring-closing metathesis reactions, South African Journal of Chemistry, 60, 2007, 1-7, R. Pathak, J.-L. Panayides, T.D. Jeftic, C.B. de Koning and W.A.L. van Otterlo.*

(29) The synthesis of the dibenzopyrrocoline alkaloid skeleton, indolo[2,1-a]isoquinoline and related analogues, Tetrahedron, 63, 2007, 2263-2274, A.N.C. Lötter, R. Pathak, T.S. Sello, M. A. Fernandes, W.A.L. van Otterlo and C.B. de Koning.*

(30) The synthesis of 2-benzazocines using ring-closing metathesis as a key step, Tetrahedron, 63, 2007, 4737-4747, J.-L. Panayides, R. Pathak, H. Panagiotopoulos, H. Davids, M.A. Fernandes, C.B. de Koning and W.A.L. van Otterlo.*

(31) Bidirectional Racemic Synthesis of the Biologically Active Quinone Cardinalin 3, Organic and Biomolecular Chemistry, 5, 2007, 2433 - 2440, S. Govender, E.M. Mmutlane, W.A.L. van Otterlo and C.B. de Koning.*

(32) Ring-opening metathesis co-polymerization of a C60-cyclopentadiene cycloadduct and norbornene with the Grubbs second generation catalyst, Fullerenes, Nanotubes and Carbon Nanostructures, 15, 2007, 341-352, M.A. Mamo, N.J. Coville* and W.A.L. van Otterlo.*

(33) Synthesis of substituted 2,3-dihydro-1H-2-benzazepines and 1,2-dihydroisoquinolines using an isomerization-ring-closing metathesis strategy. Scope and Limitations, European Journal of Organic Chemistry, 2007, 4953-4961, J.-L. Panayides, R. Pathak, C.B. de Koning and W.A.L. van Otterlo.*

(34) Alternatives to N,N-diethyl-2,4-dimethoxybenzamide as a precursor for the synthesis of 6,8-dimethoxy-3-methyl-3,4-dihydro-1H-isochromen-1-one, Synthetic Communications, 37, 2007, 3611-3621, W.A.L. van Otterlo, J.P. Michael and C.B. de Koning.*

(35) Intramolecular hydroaminations mediated by reductive mercuration or n-butyllithium to afford 3-methyl- and 3,4-dimethyl-1,2,3,4-tetrahydroisoquinolines, European Journal of Organic Chemistry, 2007, 5337-5345, R. Pathak, P. Naicker, W.A. Thompson, M.A. Fernandes, C.B. de Koning and W.A.L. van Otterlo.*

(36) Ring closing metathesis for the synthesis of 7-10-membered silicon-containing benzo-fused heterocycles, Tetrahedron Letters, 49, 2008, 7403-7405, S. Scalzullo, R. Ul Islam, G.L. Morgans, J.P. Michael and W.A.L. van Otterlo.*

(37) Efficient Nucleic Acid transduction with lipoplexes containing piperazine cholesterol derivatives, Bioorganic and Medicinal Chemistry Letters, 2009, 100-103, R. Ul Islam, J. Hean, W.A.L. van Otterlo, C.B. de Koning and P. Arbuthnot.*

(38) Simultaneous mapping of and navigation in chemical and biological space by means of hierarchical scaffold trees, Nature Chemical Biology, 5, 2009, 585-592, S. Renner, W.A.L. van Otterlo, M. Dominguez Seoane, S. Möcklinghoff, B. Hofmann, S. Wetzel, A. Schuffenhauer, P. Ertl, T.I. Oprea, D. Steinhilber, L. Brunsveld, D. Rauh, H. Waldmann.*

(39) Metathesis in the synthesis of aromatic compounds, Chemical Reviews (Invited review: Thematic Issue on “Carbenes in Chemistry”), 109, 2009, 3743-3782, W.A.L. van Otterlo* and C.B. de Koning.*

(40) The synthesis of 2- and 3-aryl indoles and 1,3,4,5-tetrahydropyrano[4,3-b]indoles and their antibacterial and antifungal activity, Bioorganic and Medicinal Chemistry Letters, 19, 2009, 4948-4951, T.C. Leboho, J.P. Michael, W.A.L. van Otterlo, S. F. van Vuuren and C. B. de Koning.*

(41) Synthetic pathway to structurally simplified analogues of pancratistatin: truncation of the cyclitol ring, Journal of Organic Chemistry, 74, 2009, 7122-7131, M. Manpadi, A.S. Kireev, I.V. Magedov,* J. Altig, P. Tongwa, M.Y. Antipin, A. Evidente, W.A.L. van Otterlo and A. Kornienko.*

(42) From natural products to achiral drug prototypes: Potent thrombin inhibitors based on P2/P3 dihydropyrid-2-one core motifs, Bioorganic and Medicinal Letters, 19, 2009, 5429-5432, S. Hanessian,* E. Therrien, J. Zhang, W.A.L. van Otterlo, Y. Xue, D. Gustafsson, I. Nilsson, and O. Fjellström.

(43) Synthesis of unsaturated 1,4-heteroatom-containing benzo-fused heterocycles using a sequential isomerization-ring-closing metathesis strategy, Tetrahedron, 65, 2009, 10650-10659, G.L. Morgans, E.L. Ngidi, L.G. Madeley, S.D. Khanye, J.P. Michael, C.B. de Koning and W.A.L. van Otterlo.*

(44) Catalytic activity of nanometal particles supported on nitrogen-doped carbon spheres, ChemCatChem, 2, 2010, 51-54, A.A. Deshmukh, R. Ul Islam, M.J. Witcomb, W.A.L. van Otterlo and N.J. Coville.*

(45) Synthesis and biological evaluation of 4-anilinoquinolines as potent inhibitors of EGFR, Journal of Medicinal Chemistry, 53, 2010, 2892-2901, V. Pawar, M. Sos, H.B. Rode, M. Rabiller, S. Heynck, W.A.L. van Otterlo, R. Thomas and D. Rauh.*

(46) Inhibition of hepatitis B virus replication in vivo using lipoplexes containing altritol-modified antiviral siRNAs, Artificial DNA: PNA & XNA, 1, 2010, 17-26, J. Hean, C. Crowther, A. Ely, R. ul Islam, K. Bloom, M.S. Weinberg, W.A.L. van Otterlo, C.B. de Koning, F. Salazar, P. Marion, E. Roesch, M. LeMaitre, P. Herdewijn and P. Arbuthnot.*

(47) The synthesis of substituted piperazine-cholesterol conjugates for use as components of nucleic acid transfection lipoplexes, South African Journal of Chemistry, 63, 2010, 88-94, R. ul Islam, M.M. Johnson, R. Mohammed, J. Hean, P. Arbuthnot, C.B. de Koning* and W.A.L. van Otterlo.*

(48) Hydrostatic pressure sensor based on carbon sphere-polyvinyl alcohol composites, Organic Electronics, 11, 2010, 1736-1739, W. Machado, P. Athayde, M.A. Mamo, W.A.L. van Otterlo, N.J. Coville and I.A. Hümmelgen.*

(49) Simple write-once-read-many-times memory device based on a carbon nanosphere-poly(vinylphenol) composite, Organic Electronics, 11, 2010, 1858-1863, M.A. Mamo, W.S. Machado, W.A.L. van Otterlo, N.J. Coville and I.A. Hümmelgen.*

(50) Characterization of irreversible kinase inhibitors by detecting fluorescent changes during covalent bond formation, ChemBioChem, 11, 2010, 2557-2566, S. Klüter, J.R. Simard, H.B. Rode, V. Pawar, H.C.A. Raaijmakers, T.A. Barf, C. Grütter, M. Rabiller, W.A.L. van Otterlo and D. Rauh.*

(51) In situ synthesis of a Pd-poly(1,8-diaminonaphthalene) nanocomposite: An efficient catalyst for Heck reactions under phosphine-free conditions, Catalysis Communications, 12, 2010, 116-121, R. Ul Islam, M.J. Witcomb, M.S. Scurrell, W.A.L. van Otterlo and K. Mallick.*

(52) CAN-mediated oxidations for the synthesis of xanthones and related products, Journal of Organic Chemistry, 75, 2010, 8701-8704, M.M. Johnson, J.M. Naidoo, M.A. Fernandes, E.M. Mmutlane, W.A.L. van Otterlo and C.B. de Koning.*

(53) Fragment-based design of novel estrogen receptor tetrahydroisoquinoline ligands, Journal of Medicinal Chemistry, 54, 2011, 2005-2011, S. Möcklinghoff, W.A.L. van Otterlo, R. Rose, S. Fuchs, T. Zimmermann, M. Dominguez Seoane, H. Waldmann, C. Ottmann and L. Brunsveld.*

(54) Application of an isomerization-ring-closing metathesis strategy to the synthesis of unsaturated seven-membered, benzo-fused heterocycles containing two heteroatoms, Tetrahedron, 67, 2011, 2991-2997, D.B. Yadav, G.L. Morgans, B.A. Aderibigbe, L.G. Madeley, M.A. Fernandes, J.P. Michael, C.B. de Koning and W.A.L. van Otterlo.*

(55) In-situ synthesis of palladium-polyaniline hybrid catalyst for Suzuki coupling reaction, Journal of Organometallic Chemistry, In press, January 2011, R. Ul Islam, M.J. Witcomb, E. van der Lingen, M.S. Scurrell, W.A.L. van Otterlo and K. Mallick.*

((56) Conjugated polymer stabilized palladium nanoparticles as a versatile catalyst for Suzuki cross-coupling reactions for both aryl and heteroaryl bromide systems, Catalysis, Science & Technology, 1, 2011, 308-315, R. Ul Islam, M.J. Witcomb, M.S. Scurrell, E. van der Lingen, W.A.L. van Otterlo and K. Mallick.*

(57) Composites of polyvinyl alcohol and carbon (coils, undoped and nitrogen doped multiwalled carbon nanotubes) as ethanol, methanol and toluene vapor sensors, Journal of Nanoscience and Nanotechnology, 11, 2011, 10211-10218, M.W.C.C. Greenshields, I.A. Hümmelgen,* M.A. Mamo, S.D. Mhlanga, W.A.L. van Otterlo and N.J. Coville.

(58) Anticancer properties of an important drug lead podophyllotoxin can be efficiently mimicked by diverse heterocyclic scaffolds accessible via one-step synthesis, Journal of Medicinal Chemistry, 54, 2011, 4234-4246, I.V. Magedov,* L. Frolova, M. Manpadi, U. devi Bhoga, H. Tang, N.M. Evdokimov, O. George, K. Hadje Georgiou, S. Renner, M. Getlic, T.L. Kinnibrugh, M.A. Fernandes, S. Van slambrouck, W.F.A. Steelant, C.B. Shuster, S. Rogelj, W.A.L. van Otterlo,* and A. Kornienko.*

(59) Metal-polymer hybrid material as a catalyst for the Heck coupling reaction under phosphine-free conditions, Synthetic Communications, 41, 2011, 3561-3572, R. Ul Islam, M.J. Witcomb, M.S. Scurrell, W.A.L. van Otterlo, E. van der Lingen and K. Mallick.*

(60) In search of a cytostatic agent derived from the alkaloid lycorine: Synthesis and antiproliferative properties of lycorine derivatives, Bioorganic and Medicinal Chemistry, 19, 2011, 7252–7261, N.M. Evdokimov, D. Lamoral-Theys, V. Mathieu, A. Andolfi, L.V. Frolova, S.C. Pelly, W.A.L. van Otterlo, I.V. Magedov, R. Kiss, A. Evidente and A. Kornienko.*

(61) A structure-based design, synthesis and biological evaluation of N-pyrazole, N’-thiazole urea inhibitors of MAP kinase p38alpha, European Journal of Medicinal Chemistry, 48, 2012, 1-15, M. Getlik, C. Grütter, J.R. Simard, H.D. Nguyen, A. Robubi, B. Aust, W.A.L. van Otterlo* and D. Rauh.*

(62) Bulbispermine: a crinine-type Amaryllidaceae alkaloid exhibiting cytostatic activity towards apoptosis-resistant glioma cells, ChemMedChem, 7, 2012, 815-822, G. Luchetti, R. Johnston, V. Mathieu, F. Lefranc, K. Hayden, A. Andolfi, D. Lamoral-Theys, M.R. Reisenauer, C. Champion, S.C. Pelly, W.A.L. van Otterlo, I.V. Magedov, R. Kiss, A. Evidente, S. Rogelj and A. Kornienko.*

(63) Formation of an unexpected rearrangement product using the Grubbs second generation catalyst – 2-allyl-3,4-dihydro-2H-1,4-benzothiazines from diene precursors, Tetrahedron Letters, 53, 2012, 2384–2387, G.L. Morgans, D.B. Yadav, M.A. Fernandes, J.P. Michael, C.B. de Koning and W.A.L. van Otterlo.*

(64) Novel Cyclopropyl-Indole Derivatives as HIV Non-Nucleoside Reverse Transcriptase Inhibitors, American Chemical Society - Medicinal Chemistry Letters, 3, 2012, 470-475, H. Mohammad, A.E. Basson, D.C. Liotta, L. Morris, W.A.L. van Otterlo and S.C. Pelly.*

(65) In Search of a treatment for HIV - Current Therapies and the Role of Non-nucleoside Reverse Transcriptase Inhibitors (NNRTIs), Chemical Society Reviews, 41, 2012, 4657-4670, C. Reynolds, C.B. de Koning, W.A.L. van Otterlo, S.C. Pelly and M.L. Bode.*

(66) Nanocomposites of gold and poly(3-hexylthiophene) containing fullerene moieties: Synthesis, characterization and application in solar cells, Journal of Power Sources, 215, 2012, 99-108, J.N. de Freitas, M.A. Mamo, M. Maubane; W.A.L. van Otterlo; N.J. Coville and A.F. Nogueira.*

(67) Aminonaphthoquinones as potential anti-breast cancer agents, African Journal of Pharmacy and Pharmacology, 6, 2012, 3102-3112, H. Davids,* R. Theunissen, S. Chakravorty, R. Mohammed, C. Frost, W.A.L. van Otterlo and C.B. de Koning.

(68) Fluorophore labeled kinase detects ligands that bind within the MAPK insert of p38a kinase, PLOS one, 7, 2012, e39713, M. Getlik, J.R. Simard, M. Termathe, C. Grütter, M. Rabiller, W.A.L. van Otterlo and D. Rauh.*

(69) Synthesis and antimicrobial activity of the essential oil compounds (E)- and (Z)-3-hexenyl nonanoate and two analogues, South African Journal of Chemistry, 65, 2012, 202-205, S. Chakravorty, M.K. Rayner, C.B. de Koning, S.F. van Vuuren* and W.A.L. van Otterlo.*

(70) Tubular shaped composites made from polythiophene covalently linked to Prato-functionalised N-doped carbon nanotubes, Synthetic Metals, 162, 2012, 2307-2315, M.S. Maubane, M.A. Mamo, E.N. Nxumalo, W.A.L. van Otterlo,* N.J. Coville.*

(71) Enhancement of transfection activity in HEK293 cells by lipoplexes containing cholesteryl nitrogen-pivoted aza-crown ethers, Medicinal Chemistry Research, 22, 2013, 2561-2569, A. Sewbalas, R. Ul Islam, W.A.L. van Otterlo, C.B. de Koning, M. Singh, P. Arbuthnot and M. Ariatti.*

(72) A ring-closing metathesis approach to eight-membered benzannelated scaffolds and subsequent internal isomerizations, Tetrahedron, 69, 2013, 2038-2047, A. Taher, B.A. Aderibigbe, G.L. Morgans, L.G. Madeley, S.D. Khanye, L. van der Westhuizen, M.A. Fernandes, V.J. Smith, J.P. Michael, I.R. Green and W.A.L. van Otterlo.*

(73) The synthesis of C60-containing polymers by ring-opening metathesis co-polymerization of a C60-cyclopentadiene cycloadduct and N-(cycloheptyl)-endo-norbornene-5,6-dicarboximide and their application in a photovoltaic device, Fullerenes, Nanotubes and Carbon Nanostructures, 21, 2013, 198-212, M.A. Mamo, F.S. Freitas, R.P. Forbes, R.S. Black, A.F. Nogueira, W.A.L. van Otterlo and N.J. Coville.*

(74) Selective derivatisation of resorcinarene ethers via an ortholithiation approach, RSC Advances, 3, 2013, 3873-3876, L. Ngodwana, D.J. Kleinhans, A.-J. Smuts, W.A.L. van Otterlo and G.E. Arnott.*

(75) Overcoming compound fluorescence in the FLiK screening assay with red-shifted fluorophores, Journal of American Chemical Society, 135, 2013, 8400-8408, R. Schneider, A. Gohla, J.R. Simard, D.B. Yadav, Z. Fang, W.A.L. van Otterlo and D. Rauh.*

(76) Synthesis and characterization of single wall carbon nanotube-grafted poly(3-hexylthiophene) and their nanocomposites with gold nanoparticles, Synthetic Metals, 176, 2013, 55-64, J.N. de Freitas, M.S. Maubane, G. Bepete, W.A.L. van Otterlo, N.J. Coville and A.F. Nogueira.*

(77) Synthesis of triazole linked 2-trichloromethylquinazolines as potential antiplasmodial agents, South African Journal of Chemistry, 53, 2013, 231-236, A.R. Hamann, P.J. Smith, W.A.L. van Otterlo and M.A.L. Blackie.*

(78) C1,C2-Ether Derivatives of the amaryllidaceae alkaloid lycorine: retention of activity of highly lipophilic analogues against apoptosis-resistant cancer cells, Bioorganic and Medicinal Chemistry Letters, 24, 2014, 923-927, R. Dasari, L. Moreno Y Banuls, M. Masi, S.C. Pelly, V. Mathieu, I.R. Green, W.A.L. van Otterlo, A. Evidente, R. Kiss and A. Kornienko.*

(79) Synthetic and biological studies of tubulin targeting C2-substituted 7-deazahypoxanthines derived from marine alkaloid rigidins, ChemMedChem, 9, 2014, 1428-1435, R. Scott, M. Karki, M.R. Reisenauer, R. Rodriguez, R. Dasari, W.R. Smith, F. Lefranc, S.C. Pelly, W.A.L. van Otterlo, C.B. Shuster, R. Kiss, S. Rogelj, I.V. Magedov, L.V. Frolova* and A. Kornienko.*

(80) Synthesis of novel piperazine-linked anthranilic acids as potential small molecule kinase inhibitors, South African Journal of Chemistry, 67, 2014, 71-79, S. Chakraborty, H.F. Klein, L.E. Hodson, M. Rabillier, Z. Fang, A. Richters, S.C. Pelly, D. Rauh* and W.A.L. van Otterlo.*

(81) Synthesis of 4-azapodophyllotoxins with anticancer activity by multicomponent reactions, Chemistry of Heterocyclic Compounds, 50, 2014, 119-138, M.G. Botes, S.C. Pelly, M.A.L. Blackie, A. Kornienko and W.A.L. van Otterlo.*
(82) Novel indole based NNRTIs with improved potency against wild type and resistant HIV, Bioorganic and Medicinal Chemistry Letters, 24, 2014, 4376-4380, R. Müller, I. Mulani, A. Basson, M. Hassam, N. Pribut, L. Morris, W.A.L. van Otterlo and S.C. Pelly.*

(83) Novel triazole-linked mefloquine analogues: biological evaluation against Plasmodium falciparum, Bioorganic and Medicinal Chemistry Letters, 24, 2014, 5466-5469, A.R. Hamann, C. de Kock, P.J. Smith, W.A.L. van Otterlo and M.A.L. Blackie.*

(84) Stealth lipoplexes decorated with click chemistry-tethered galactosyl moieties: Strongly hepatotropic vectors, Biotechnology Letters, 37, 2015, 567-575, D. Govender, R. Ul Islam, C.B. de Koning, W.A.L. van Otterlo, P. Arbuthnot, M. Ariatti* and M. Singh.

(85) Towards a cancer drug of fungal origin, Medicinal Research Reviews, 35, 2015, 937-967, A. Kornienko, A. Evidente, M. Vurro, V. Mathieu, A. Cimmino, M. Evidente, W.A.L. van Otterlo, R. Dasari, F. Lefranc and R Kiss.*

(86) Isomerization of allylbenzenes, Chemical Reviews, 115, 2015, 5462-5569, M. Hassam, A. Taher, G.E. Arnott, I.R. Green and W.A.L. van Otterlo.*

(87) Covalent-allosteric kinase inhibitors, Angewandte Chemistry, International Edition, 54, 2015, 10313-10316, J. Weisner, R. Gontla, L. van der Westhuizen, S. Oeck, J. Ketzer, P. Janning, A. Richters, T. Mühlenberg, Z. Fang, A. Taher, V. Jendrossek, S. Bauer, S.C. Pelly, W.A.L van Otterlo and D. Rauh.*

(88) Synthesis of diverse 6-oxa-allocolchicinoids by a Suzuki-Miyaura coupling followed by an acid-catalyzed-intramolecular-transacetalization, European Journal of Organic Chemistry, 2015, 5167-5182, D.B. Yadav, L. Taleli, A. van der Westhuyzen, M.A. Fernandes, M. Dragoun, A. Prokop, H.-G. Schmalz, C.B. de Koning and W.A.L. van Otterlo.*

(89) In vitro antiplasmodial activity of triazole-linked chloroquinoline derivatives synthesized from 7-chloro-N-(prop-2-yn-1-yl)quinolin-4-amine, Bioorganic and Medicinal Chemistry, 23, 2015, 4163-4171, L. Taleli, C. de Kock, P.J. Smith, S.C. Pelly, M.A.L. Blackie and W.A.L. van Otterlo.*

(90) Wittig derivatization of sesquiterpenoid polygodial leads to cytostatic agents with activity against drug resistant cancer cells and capable of pyrrolylation of primary amines European Journal of Medicinal Chemistry, 103, 2015, 226-237, R. Dasari, A. De Carvalho, D.C. Medellin, K.N. Middleton, F. Hague, M.N.M. Volmar, L.V. Frolova, M.F. Rossato, J.J. De La Chapa, A. Pillai, V. Mathieu, S. Rogelj, C.B. Gonzales, J.B. Calixto, A. Evidente, M. Gautier, G. Munirathinam, R. Glass, P. Burth, S.C. Pelly, W.A.L. van Otterlo, R. Kiss and A. Kornienko.*

(91) Design, synthesis and evaluation of novel ferroquine and phenylequine analogues as potential antimalarial agents, Submitted to ChemMedChem, Accepted - September 2015, L. Jacobs, C. de Kock, K.A. de Villiers, P.J. Smith, V.J. Smith, W.A.L. van Otterlo and M.A.L. Blackie.*

(92) Aberrant apoptotic response of colorectal cancer cells to novel nucleoside analogues, PLoS ONE, 10, 2015, e0138607, N. Dahan-Farkas, J.-L. Panayides, W.A.L. van Otterlo, C. Penny and L. Harmse.*

(93) Synthetic and biological studies of sesquiterpene polygodial: activity of 9-epipolygodial against drug resistant cancer cells, ChemMedChem, 10, 2015, 2014-2026, R. Dasari, A. De Carvalho, D.C. Medellin, K.N. Middleton, F. Hague, M.N.M. Volmar, L.V. Frolova, M.F. Rossato, J.J. De La Chapa, A. Pillai, V. Mathieu, S. Rogelj, C.B. Gonzales, J.B. Calixto, A. Evidente, M. Gautier, G. Munirathinam, R. Glass, P. Burth, S.C. Pelly, W.A.L. van Otterlo, R. Kiss and A. Kornienko.*

(94) Novel microtubule-targeting 7-deazahypoxanthines derived from marine alkaloid rigidins with potent in vitro and in vivo anticancer activities, Journal of Medicinal Chemistry, 59, 2016, 480-485, D.C. Medellin, Q. Zhou, R.M. Hill, S. Frail, R. Dasari, S.J. Ontiveros, R. Scott, S.C. Pelly, W.A.L. van Otterlo, T. Betancourt, C.B. Shuster, E. Hamel, D.V. LaBarbera, S. Rogelj, L.V. Frolova* and A. Kornienko.*

(95) Spacer length: A determining factor in the design of galactosylated ligands for hepatoma cell-specific gene delivery, Accepted to Current Drug Delivery with corrections, January 2016, L. Mbatha, R. Ul Islam, C.B. de Koning, W.A.L. van Otterlo, M. Ariatti* and M. Singh.

(96) Novel indole sulfides as potent stable HIV-1 NNRTIs, Bioorganic and Medicinal Chemistry Letters, Accepted with minor corrections, February 2016, S. Brigg, N. Pribut, A.E. Basson, R. Venter, M. Avgenikos, W.A.L. van Otterlo and S.C. Pelly.*


 < PUBLISHED CRYSTALLOGRAPHIC COLLABORATIONS

1) 6,8-Dimethoxy-1,3-trans-dimethylisochroman-5-yl diethyl phosphate, Acta Crystallographica, 2002, E58, o440-o441, L. Cook, C.B. de Koning, M.A. Fernandes, J.P. Michael and W.A.L. van Otterlo.*

(2) 5,8-Dimethoxy-3-methylisochromane, Acta Crystallographica, E59, 2003, o992-o993, C.B. de Koning,* M.A. Fernandes, L.K. Li, J.P. Michael and W.A.L. van Otterlo.

(3) N-{3-Isopropoxy-4-methoxy-2-[(1E)-1-propenyl]benzyl}(phenyl)methanesulfonamide, Acta Crystallographica, E60, 2004, o1586-o1588, W.A.L. van Otterlo,* J.-L. Panayides and M.A. Fernandes.

(4) 1-[3,5-Bis(bromomethyl)-2,4,6-trimethoxybenzyl]-3,5-bis(bromomethyl)-2,4,6-trimethoxybenzene, Acta Crystallographica, E62, 2006, o168-o170, G.L. Morgans, W.A.L. van Otterlo,* J.P. Michael and M.A. Fernandes.

(5) 1-benzyl-3,3-dichloro-1,3-dihydro-2H-indol-2-one, Acta Crystallographica, C63, 2007, o157-o159, A.N.C. Lotter, M.A. Fernandes, W.A.L. van Otterlo and C.B. de Koning.*

(6) 2-{[(4-methylphenyl)sulfonyl]amino}phenyl 4-methylbenzenesulfonate, Acta Crystallographica C, C63, 2007, o309-o311, G.L. Morgans, S.M. Scalzullo, M.A. Fernandes,* J.P. Michael and W.A.L. van Otterlo.*

(7) b-Amyrin benzoate, Acta Crystallographica E, E63, 2007, o3032-o3033, G.W. Perold, R.S. Black, A. Lemmerer,* J.P. Michael and W.A.L. van Otterlo.

< PATENTS

(1) Title: New 5,6-dihydopyridin-2-one compounds useful as inhibitors of thrombin, International Patent Application Number PCT/SE2004/001878 (0303452-7, Sweden), Filing date 15 December 2004; Inventors: K. Berggren, O. Davidsson, O. Fjellström, D. Gustafsson, S. Hanessian, T. Inghardt, M. Nagard, I. Nilsson, E. Therrien and W.A.L. van Otterlo.

(2) Title: Novel NNRTIs based on a cyclopropylindole skeleton, South African patent application 2011; Inventors: H. Mohammad, W.A.L. van Otterlo and S.C. Pelly.

(3) Title: Substituted indoles, South African patent application 2013 No 2013/07447; Inventors: S.C. Pelly,* W.A.L. van Otterlo, R. Müller and A. Basson.

< BOOK CHAPTERS

(1) Oxepines and Azepines, D.L. Riley and W.A.L. van Otterlo, in "Heterocycles in Natural Product Synthesis", Editors: K.C. Majumdar and S.K. Chattopadhyay, Wiley-VCH Verlag, Weinheim Germany, 2011, 537-568.

(2) Ring-Closing Metathesis: Synthetic routes to carbocyclic aromatic compounds using ring-closing ene-ene and ene-yne metathesis, C.B. de Koning and W.A.L. van Otterlo, in "Arene Chemistry: Reaction: Mechanisms and Methods for Aromatic Compounds", Editor: J. Mortier, Wiley, Hobroken, 2015, in press.






   


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